Researchers Warn: Don’t Mix Grapefruit, Some Prescriptions

Before you toss that gorgeous grapefruit into your grocery cart, think twice. Canadian researchers say that grapefruit plus some prescription medications can be deadly, or at least cause severe side effects.

Researchers from Ontario’s Lawson Health Research Institute first studied interactions between the fruit and certain prescription medications two decades ago. According to Medical News Today, the number of drugs known to cause heavy-duty side effects when combined with grapefruit has jumped from 17 to 43 between 2008 and 2012. A total of 85 drugs might have some type of interaction. Scientists attribute the big increase to new drugs and formulations.

The Mayo Clinic says in addition to grapefruit, other citrus foods like pomelos and Seville oranges can interfere with certain types of medications even when you ingest them at different times. The interaction occurs when chemicals in the food interfere with enzymes that metabolize certain drugs in the digestive tract. When the medication doesn’t break down properly, it can reach dangerous levels and cause serious side effects.

Among medications likely affected are some anti-anxiety, anti-arrhythmia, antidepressant, antihistamine, anti-retroviral, and anti-seizure drugs. Also on the list are calcium channel blockers, immunosupressants, and statins.

The Canadian researchers found that medications with potential interactions share a trio of traits: they’re administered orally; the enzyme CYP3A4 is tied to their metabolism in the gut; the amount of the medication that reaches the bloodstream unaltered is in the low to mid-range.

Among the most serious side effects are respiratory failure, gastrointestinal bleeding, and renal toxicity. Also possible are bone marrow suppression, acute kidney failure, and even death.

The U.S. Food and Drug Administration (FDA) offers tips for consumers who enjoy grapefruit products. Safety should start by asking a pharmacist or medical provider whether it’s all right to consume grapefruit products while taking a medication. If not, the FDA says it’s wise to also ask if other juices are allowable. Patients can also check the prescription‘s medication guide or sheet for a mention of grapefruit.

The agency suggests it’s prudent to read labels of non-prescription medications and check other juices in the home to see if they contain products made from grapefruit, Seville oranges, or tangelos.

I had to give away a gigantic pink grapefruit a few years ago. As a patient on the same drugs for Crohn’s disease for years, I had become lax about reading patient inserts. As I left my surgeon’s office, he wished me happy holidays, then cautioned me against consuming any alcohol, even in fruitcake, because of one medication. When I mentioned buying the pink grapefruit, he quickly told me it wasn’t allowed either.

The potential interaction from mixing grapefruit and some prescription medications should be a wake-up call for those of us who cavalierly toss product inserts, unread, as soon as we open a prescription.

Vonda J. Sines has published thousands of print and online health and medical articles. She specializes in diseases and other conditions that affect the quality of life.

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The Needless Tragedy of Student Loan Defaults

For the first time on record, the delinquency rate on student loans has jumped above the rate for credit cards, car loans, or any other kind of consumer loan. The tragedy? Many of those loans will default, with stunningly harsh consequences, even though there are many good options for debt relief—deferment, forebearance, or reductions in monthly payments.

“There is actually no rational reason for a borrower to be delinquent or default on their loans,” says Mark Kantrowitz, president of MK Consulting in Cranberry Township, Pa., and operator of the FinAid.org website.

Borrowers who are unemployed, in the military, or back in school can ask for up to three years or full or partial deferment on repayment of a federal loan. For those who have a job but don’t earn enough to cover the monthly payment, there are six options: graduated repayment, extended repayment, income-based repayment, income-contingent repayment, income-sensitive repayment, and pay-as-you-earn repayment. In other words, the federal government will do just about anything to keep borrowers from giving up and walking away completely.

If that’s the carrot, here’s the stick: Defaulting is “like a trip through hell with no light at the end of tunnel,” says Kantrowitz. The federal government can garnish up to 15 percent of a borrower’s wages, Social Security disability, and Social Security retirement income without a court order. Unlike other debt, student loans can’t be discharged in bankruptcy. Collection charges of up to 20 percent can be skimmed off the top of payments—enough to turn a 10-year loan into a 19-year loan. To say nothing of the lasting damage to a borrower’s credit score, which will make it hard or impossible to get a credit card, auto loan, or mortgage.

And, oh, by the way, if you win the lottery, the first winner from your windfall is the Education Department.

With that kind of downside, why do so many people default on their student loans? Some may not understand their options, or put off dealing with the problem. Also, research shows that many borrowers consider their student loans illegitimate and don’t feel they should have to pay them back. In fact, default rates are four times as high for dropouts, who presumably feel they didn’t get their money’s worth.

There’s a cyclical factor, too. The Federal Reserve Bank of New York reported on Nov. 27 that the percentage of student loan balances that were 90 or more days delinquent rose to 11 percent in the July-September quarter, higher than the delinquency rate on credit cards since the survey began in 2003. The spike comes at a time when youth unemployment remains historically high. Even for those with jobs, people are paying ever more money for educations that don’t equip them for jobs that pay them enough to cover their debts, as I wrote earlier this year in “Debt for Life.”

At the same time, delinquency rates on credit cards, auto loans, and mortgages have been falling because bad credit has been washed out of the system. There’s no such cleansing mechanism for student debt, which now totals $ 956 billion in outstanding loans, according to the New York Fed. The federal Consumer Financial Protection Bureau, using different methodologies, says student loan debt passed the $ 1 trillion mark sometime last winter.

Then there’s the fact that some of these student borrowers were probably lousy bets for repayment in the first place. The federal government, which holds 85 percent of outstanding student debt, doesn’t make loans to students based on their ability to repay them. That may sound crazy, but it is designed to ensure that students of all backgrounds and income levels get a shot at a college degree.

That willful blindness also sets up the government for huge losses. The purpose of the draconian punishment for defaulters is to make up for the lack of sound underwriting on the original lending. Clearly, though, the threats aren’t working—and neither are the multiple repayment options the government offers.

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Rugby-England add flyhalf Burns to squad for All Blacks’ test

LONDON, Nov 27 (Reuters) – England called up uncapped Gloucester flyhalf Freddie Burns on Tuesday to their squad for Saturday’s test against New Zealand in place of the injured Toby Flood.

Flood sustained ligament damage to a big toe during the 16-15 loss to South Africa at Twickenham last Saturday.

Owen Farrell, whose last start was in the first test in South Africa this year, is set to replace Flood in the starting XV against the world champions.

Lock Courtney Lawes, who missed England’s first three tests of the November series because of a knee injury, has also been included in the 23-man squad. Two other locks, Mouritz Botha and Tom Palmer, have been omitted.

After beating Fiji in their opening match, England have lost to Australia and the Springboks and now face a daunting match against the All Blacks who are unbeaten in 20 tests since the start of their victorious World Cup campaign last year.

“For those in Saturday’s squad the message is clear – last week we went toe to toe with the second best team in the world and felt we should have won,” England head coach Stuart Lancaster said in a statement.

“Now we have a chance to take on the number one side in front of a passionate Twickenham crowd, who have been fantastic throughout the Internationals, and it is a challenge we will meet head on.” (Reporting by John Mehaffey; Editing by Ken Ferris)

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The Wii U sells out in its first week: Evidence of a Nintendo comeback?

The latest console from the videogame pioneer is flying off the shelves. But are the kids really still into Mario and Zelda?

Earlier this year, Nintendo posted its first annual loss in three decades, a grim omen for the pathbreaking videogame maker that introduced the world to classic characters like Mario, Donkey Kong, and Link. The Japanese company has struggled amidst an industry-wide decline in the sales of consoles and games, a trend partly attributed to the ever-growing popularity of tablets and smartphones. Nintendo’s last breakout success was the Wii, released in 2006, and there have been serious doubts that its successor, the Wii U, could sell as many units. However, since the Wii U went on sale in North America on Nov. 18, Nintendo has completely sold out of all 400,000 consoles shipped to retailers. “As soon as the Wii U hits the shelf, it’s selling out,” said Reggie Fils-Aime, the head of Nintendo’s U.S. operations.

The Wii U’s early success is a surprising indication of “strong demand for the company’s next generation of videogame devices,” says Ian Sherr at The Wall Street Journal. And during the week of Nov. 18, Nintendo also sold 300,000 units of the original Wii, as well as more than 500,000 units of its portable DS and 3DS systems, which could reflect a rebound in consumer demand as the economy continues its long slog of a recovery from the Great Recession. Nintendo says it expects to sell 5.5 million Wii U systems by the end of March 2013, the end of its fiscal year.

However, it’s important to remember that “Nintendo has a very dedicated audience that craves almost anything new the company has to offer, not unlike Apple’s fans,” says Nick Wingfield at The New York Times. “The real test of the Wii U’s durability will come when the product is in better supply and more casual gamers, who don’t dream about Mario and Zelda in their sleep, can more easily buy it.” In addition, rivals Sony and Microsoft are expected to unveil their new consoles sometime in 2013, putting extra pressure on Nintendo. 

And perhaps most importantly, Nintendo has to sell games. The Wii U — which retails for $ 299.99, and $ 349.99 for a more powerful model — is being sold at a loss. Nintendo hopes that users will continue to buy games in the years to come, particularly those that aren’t sold on other systems, such as the latest installments in the “Super Mario Bros.” and “Legend of Zelda” franchises. That’s among the keys to Nintendo’s future profitability.

Sources: The Los Angeles Times, The New York Times, USA Today, The Wall Street Journal

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Turkish PM fumes over steamy Ottoman soap opera

ISTANBUL (Reuters) – A hit TV show about the Ottoman Empire‘s longest-reigning Sultan has raised a political storm in Turkey, with Prime Minister Tayyip Erdogan urging legal action over historical inaccuracies and the opposition accusing him of artistic tyranny.

Erdogan tore into the weekly soap opera “Magnificent Century”, which attracts an audience of up to 150 million people in Turkey as well as parts of the Balkans and Middle East, in response to criticism of his government’s foreign policy.

The lavish television production, which grips audiences with tales of power struggles and palace intrigue, is set during the 16th century reign of Suleiman the Magnificent, when Ottoman rulers held sway over an empire straddling three continents.

Bristling at suggestions that Turkey was meddling too much in its neighbors’ affairs, Erdogan recalled Turkey’s heritage, and said Suleiman had been a proud conqueror rather than the indulgent harem-lover portrayed in the show.

“(Critics) ask why are we dealing with the affairs of Iraq, Syria and Gaza,” Erdogan said at the opening of an airport in western Turkey on Sunday.

“They know our fathers and ancestors through ‘Magnificent Century’, but we don’t know such a Suleiman. He spent 30 years on horseback, not in the palace, not what you see in that series.”

Scenes that showed Suleiman with women in the harem have prompted calls from viewers in the mostly Muslim and largely conservative country for the broadcasting regulator (RTUK) to ban the series. But it tops the viewing charts each week.

Erdogan said the director of the series, which has been on air since January 2011, and the owner of the channel that broadcasts it had been warned, but also said he expected the judiciary to act, without elaborating.

Erdogan’s opponents accused him of authoritarianism.

“The prime minister must be jealous of the series’ popularity. He thinks there’s no need for another sultan when he’s in power,” said Muharrem Ince, the deputy chairman of the main opposition Republican People’s Party (CHP).

“Erdogan wants to be the only sultan.”

Elected a decade ago with the strongest majority seen in years, Erdogan has overseen a period of unprecedented prosperity in Turkey. But concerns are growing about his increasingly authoritarian rule.

Hundreds of politicians, academics and journalists are in jail on charges of plotting against the government, while more than 300 army officers were given prison terms in September for conspiring to topple him not long after he swept to power.

Turkey has been increasingly assertive in regional politics, most notably over the crisis in neighboring Syria, where it has led calls for international action and scrambled war planes in a warning to Damascus not to violate its territory.

“I think the prime minister’s aim here is to change the agenda. I can’t think of any other reason to discuss an imaginary television series when there are so many problems in a country,” Nebahat Cehre, who played Suleiman’s mother during the first two seasons, told Turkey’s Birgun newspaper.

(Editing by Nick Tattersall and Jon Hemming)

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Former presidential nominee Dole in hospital: media reports

WASHINGTON (Reuters) – Former Republican presidential nominee Bob Dole has been admitted to Washington’s Walter Reed Army medical center for what an aide called a “routine procedure,” media reports said on Tuesday.

Dole, 89, “self-checked into the hospital for a routine procedure and will be discharged tomorrow,” an aide told NBC News. “He’s doing very well.”

According to Politico, Senate Majority Leader Harry Reid, a Democrat, said on the Senate floor on Tuesday that Dole was hospitalized “because he is infirm. He is sick.”

Reid’s comments came during debate on the U.N. Convention on the Rights of Persons with Disabilities. Dole, who was severely wounded during World War Two, had sent a letter to the Senate urging passage.

Dole, a former Senate majority leader from Kansas, lost the 1996 presidential election to Democratic incumbent Bill Clinton. Dole served as a senator from 1969 to 1996.

(Reporting by Ian Simpson; Editing by Paul Simao)

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U.S. declines to name China currency manipulator

WASHINGTON (Reuters) – The Obama administration on Tuesday said China‘s currency remained “significantly undervalued” but stopped short of labeling the world’s second-biggest economy a currency manipulator.

In a congressionally mandated semi-annual report, the U.S. Treasury noted that yuan had risen 12.6 percent against the U.S. dollar in inflation-adjusted terms since June 2010. An official said it was up 9.7 percent on a nominal basis through Tuesday, when it closed at a record high.

Although Beijing keeps the yuan, also known as the renminbi, in a tight trading band, the Treasury said China did not meet the legal requirements to be deemed a currency manipulator. The label is largely symbolic but would require Washington to open discussions with Beijing on adjusting the yuan’s value.

The Chinese government had “substantially” reduced its intervention in foreign exchange markets since the third quarter of 2011 and loosened capital controls, the Treasury said in the report, which examines the currency practices of major U.S. trading partners.

“In light of these developments, Treasury has concluded that the standards … have not been met with respect to China,” it said. “Nonetheless, the available evidence suggests the renminbi remains significantly undervalued.”

During the U.S. presidential campaign, Republican candidate Mitt Romney pledged to label China a manipulator on his first day in office to show he would be tougher on the United States’ chief economic competitor than President Barack Obama.

Many U.S. businesses and lawmakers complain that China keeps the value of its currency artificially low to gain an advantage in trade.

But an international consensus is growing that the yuan is closing in on its fair value after about a decade at an artificially weak level. The International Monetary Fund softened its language on the yuan in July.

YUAN AT RECORD HIGH

The yuan closed at a record high on Tuesday as the central bank’s reluctance to let the currency rise more quickly limited trading activity.

The People’s Bank of China limits currency moves by allowing the yuan to rise or fall by only 1 percent from whatever rate the central bank sets that day.

It has been 18 years since the U.S. Treasury has designated any country a currency manipulator. China was so labeled five times from May 1992 to July 1994.

Charles Schumer, the No. 3 Democrat in the Senate and a longtime critic of China’s yuan policy, said the Treasury should label China a manipulator to be able to impose penalties on it.

“It’s time for the Obama administration to rip off the band-aid, and force China to play by the same rules as all other countries,” the New York senator said in a statement.

But the U.S.-China Business Council, which represents about 240 American companies that do business with China, applauded the latest decision.

“The exchange rate has little to do with the U.S. trade balance or employment,” council President John Frisbie said. “We need to move on to more important issues with China, such as removing market access barriers and improving intellectual property protection.”

The Treasury said further appreciation of the yuan would help China balance its economy toward consumption by giving households greater purchasing power.

The report also called on China to reduce its “exceptionally high” foreign exchange reserves and to publish data about its intervention in currency markets.

The Obama administration also used the report to keep pressure on South Korea to limit its intervention in foreign exchange markets.

South Korea says it intervenes to smooth the volatility of its won currency, but it has gone into the market throughout 2012, the Treasury report said. In July, the IMF said the won was undervalued by up to 10 percent.

“We will continue to press the Korean authorities to limit their foreign exchange interventions to the exceptional circumstances of disorderly market conditions,” the report said.

(Reporting by Anna Yukhananov, additional reporting by Doug Palmer; Editing by James Dalgleish and Dan Grebler)

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Dog days in Cuba: from shih tzus to schnauzers

HAVANA (AP) — The Cuban capital has played host to political summits and art festivals, ballet tributes and international baseball competitions. Now dog lovers are getting their chance to take center stage.

Hundreds of people from all over Cuba and several other countries came to a scruffy field near Revolution Plaza this past week to preen and fuss over the shih tzus, beagles, schnauzers and cocker spaniels that are the annual Fall Canine Expo’s star attractions. There were even about a dozen bichon habaneros, a mid-sized dog bred on the island since the 17th century.

As dog lovers talked shop, the merely curious strolled the field, checking out the more than 50 breeds on display while carefully dodging the prodigious output of so many dogs.

The four-day competition, which ended Sunday, included competitions in several breeding categories, and judges were flown in from Nicaragua, Colombia and Mexico.

“This is a small, poor country, but Cubans love dogs,” said Miguel Calvo, the president of Cuba’s dog federation, which organized the show. “We make a great effort to breed purebred animals of quality.”

Winners don’t receive any trophy or prize money, but that doesn’t mean the competition is any less fierce.

Anabel Perez, owner of a cocker spaniel named Lisamineli after the U.S. actress, spent more than half an hour coifing the dog’s hair in preparation for the competition, while the owner of a shih tzu named Tiguer meticulously brushed his coat nearby.

“I’m a hairdresser for humans,” explained Tiguer’s owner, Miguel Lopez. “So it’s easy for me. I like shih tzus because they are a lot of work to keep well groomed.”

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HP hit with civil securities lawsuit over Autonomy deal

SAN FRANCISCO (Reuters) – Hewlett-Packard Co was sued on Monday by an investor who claimed the company knew statements about its Autonomy acquisition were misleading and led the stock to fall, according to lawyers representing the plaintiff.

The proposed class action lawsuit was filed in a San Francisco federal court.

HP dropped a bombshell last Tuesday with an $ 8.8 billion write-down on its acquisition of British software firm Autonomy, saying the company inflated sales with improper accounting. Autonomy co-founder Mike Lynch has denied any wrongdoing.

HP bought Autonomy for a hefty $ 11.1 billion last year. HP has said it alerted regulators on both sides of the Atlantic.

The lawsuit, one of the first to be filed by investors on the Autonomy mess, said HP hid the fact it gained control of Autonomy based on financial statements that could not be relied upon. It also said that HP had not revealed to investors that it tried to undo the Autonomy agreement before it closed because of the accounting issues.

(Reporting By Dan Levine and Poornima Gupta; Editing by Gerald E. McCormick and Andre Grenon)

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Actor: CBS comedy ‘Two and a Half Men’ is ‘filth’

NEW YORK (AP) — The teenage actor who plays the half in the hit CBS comedy “Two and a Half Men” says it’s “filth” and through a video posted by a Christian church has urged viewers not to watch it.

Nineteen-year-old Angus T. Jones has been on the show since he was 10 but says he doesn’t want to be on it. He says, “Please stop watching it. Please stop filling your head with filth.”

The video was posted by the Forerunner Christian Church in California, where Jones says he went to meet his spiritual needs.

Show producer Warner Bros. Television has no comment. CBS hasn’t responded to a request for comment left Monday.

The show stars Jon Cryer as Jones’ uptight dad and originally featured Charlie Sheen as his hedonistic philandering uncle, but Sheen was replaced by Ashton Kutcher.

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